Goat anti HIV-1 gp41 ecto domain
This purified polyclonal IgG antibody fraction against recombinant HIV-1 gp41. Raised by the conjugation of purified recombinant antigen onto a proprietary muramyl dipeptide like microparticle adjuvant designed to elicit high titer antibody responses. This antibody formulation was used as a portion of the antibody cocktail comprising the drug PEGRG214 tested in FDA approved human clinical trials.
Western blot analysis shows very strong reactivity against gp41, gp120 and gp160 on Genlabs HIV strips. EIA anaysis utilising adapted Abbott EIA hardware and reagents produces very high apparent reactivity against Abbott Diagnostics bead antigens. Epitope mapping results employing the HIV-1MN envelope peptide set from the NIH AIDS Research and Reference Reagent Program (amino acid sequence 1 – 856) demonstrate strong activity to HIV peptides contained between amino acid sequence gp160 483 – 620 = gp41 sequence 1 – 109.
Supplied as a sterile 9mg/ml solution in 0.15M NaCl.
For non human research use only.
Antigen source: Fitzgerald Industries International, MA, USA.
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